There's Something About Mary vs. The 40-Year-Old Virgin

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Ouch, tough call. I think 40-year-old edges this one out.

Two summer comedy sensations. 40 Year Old Virgin just feels much more organic to me.

Got to go with the Farrelly brothers here

Something About Mary and 40-Year-Old Virgin are the two films which are impossibly similar in terms of quality. They are both very watchable, hilarious comedies that are also quotable. Right now, my heart is saying Mary, so I'll pick that.

They should do a mashup: There's Something About The 40-Year-Old Virgin Mary. It could be a religious sex comedy!