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These were both on cable a lot when I was younger. Night of the Comet is an apocalyptic Sci-Fi comedy while Dead Heat is a zombie Sci-Fi comedy. Just off the top of my head, I would say that Night of the Comet is more fun, and I like the female protagonists a lot. Dead Heat has a sicker sense of humor and more gore, but I've never enjoyed it that much. I'm not sure if Joe Piscopo had anything to do with it.