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this is a hard pick, both re-invented their sub genre of horror during a dead period.
Going with the Fast Infected people AKA Zombies-its one of the 10 best Zombie films so Ill take it over the Very Smart and cool Scream but its close, both top 100 greatest Horror films.
28 Days has a good start, but it gets pretty tiring towards the end. Scream is an all out well paced horror masterpiece. So it wins.
What's wrong zombie, it looks like you've seen a ghost?